GPX4 Promoter Hypermethylation Induced by Ischemia/Reperfusion Injury Regulates Hepatocytic Ferroptosis
Ferroptosis may be the primary mode of cell death in hepatocytes following ischemia-reperfusion injury. The methylation of the <i>GPX4</i> promoter and elevated levels of global hepatic methylation are involved in the regulation of ferroptosis.
Authors
- Jiying Jiang (ORCID: https://orcid.org/0009-0003-4273-2509)
- Jiao Liu (ORCID: https://orcid.org/0000-0002-6801-253X)
- Peilun Xiao (ORCID: https://orcid.org/0000-0001-8759-9033)
- Yue Jiao (ORCID: https://orcid.org/0000-0001-9872-6034)
- Jiaqi Fan (ORCID: https://orcid.org/0009-0002-3541-7984)
- Yuting Chen (ORCID: https://orcid.org/0000-0002-9177-1753)
- Chen Bai (ORCID: https://orcid.org/0000-0003-4560-3019)
- Yuexia Zhang (ORCID: https://orcid.org/0000-0001-5416-5714)
- Fangfang Chu
- Shuna Yu (ORCID: https://orcid.org/0000-0001-5537-995X)
Institutions
- Weifang Medical University (CN)
Publication Details
- Journal
- Journal of Clinical and Translational Hepatology
- Published
- 2024-10-18
- DOI
- https://doi.org/10.14218/jcth.2024.00135
- Citations
- 5
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.17