Synthesis of 2‐Pyrones by Base‐Induced [3+3] Annulation Reaction of Phenacyl Phosphonium Ylides with Cyclopropenones
Abstract The base‐induced [3+3] annulation reaction of phenacyl phosphonium ylides with cyclopropenones has been proposed. Various polysubstituted 2‐pyrones are achieved in moderate to good yields through C−P bond cleavage and C−O/C−C coupling under simple and easy‐to‐operate conditions. The synthetic application and reaction mechanism have also been preliminarily explored to gain a deeper understanding of this strategy in practicality and reaction details. This protocol offers an alternative approach for the synthesis of useful 2‐pyrone derivatives.
Authors
- Kelu Yan (ORCID: https://orcid.org/0000-0002-1551-267X)
- Jiangwei Wen (ORCID: https://orcid.org/0000-0002-4431-9158)
- W. C. Xue (ORCID: https://orcid.org/0000-0001-8664-5085)
- Xiaoyu Wang (ORCID: https://orcid.org/0000-0002-8641-2430)
- Yuanyuan Zhang (ORCID: https://orcid.org/0000-0002-7392-8403)
- Hongjun Liu (ORCID: https://orcid.org/0000-0001-5408-2337)
- Qiuyun Li (ORCID: https://orcid.org/0009-0007-3000-2444)
Institutions
- Qufu Normal University (CN)
- Yancheng Institute of Technology (CN)
Publication Details
- Journal
- Asian Journal of Organic Chemistry
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1002/ajoc.202400333
- Citations
- 2
- Primary Topic
- Cyclopropane Reaction Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.50
Funders
- National Natural Science Foundation of China