Combined dapagliflozin and roxadustat effectively protected heart and kidney against cardiorenal syndrome-induced damage in rodent through activation of cell stress-Nfr2/ARE signalings and stabilizing HIF-1α
Combined DAPA-ROX therapy has a synergistic effect on protecting heart and kidney functions against CRS-induced damage in rodents.
Authors
- John Y. Chiang (ORCID: https://orcid.org/0000-0002-8719-4017)
- Pei‐Hsun Sung (ORCID: https://orcid.org/0000-0002-1989-9752)
- Ya Yue
- Hon‐Kan Yip (ORCID: https://orcid.org/0000-0002-6305-5717)
- Ben‐Chung Cheng
- Chih‐Chao Yang (ORCID: https://orcid.org/0000-0003-0049-5181)
- Yi-Ling Chen
- Han‐Tan Chai
Institutions
- National Sun Yat-sen University (TW)
- Kaohsiung Medical University (TW)
- China Medical University (TW)
- Kaohsiung Chang Gung Memorial Hospital (TW)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- China Medical University Hospital (TW)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1016/j.biopha.2024.117567
- Citations
- 6
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 2.15
Funders
- Ministry of Science and Technology, Taiwan