Metatranscriptomic insights into the dengue patient blood microbiome: Enhanced microbial diversity and metabolic activity in severe patients
Our metatranscriptomic approach provides a species-level characterization of blood microbiome composition and reveals a heightened diversity of TAMs in patients with severe dengue, underscoring the need for further research into the role of blood microbiota in disease progression. Comparing the microbial signatures across the severity classes early in the disease offers unique potential for convenient and early diagnosis of dengue infection.
Authors
- Pallawi Kumari
- Aanchal Yadav
- Rajesh Pandey (ORCID: https://orcid.org/0000-0002-4404-8327)
- Uzma Shamim (ORCID: https://orcid.org/0000-0001-8757-1209)
- Bansidhar Tarai (ORCID: https://orcid.org/0000-0001-9742-9855)
- Sandeep Budhiraja (ORCID: https://orcid.org/0000-0002-5981-7280)
- Priti Devi
Institutions
- Indraprastha Institute of Information Technology Delhi (IN)
- Institute of Genomics and Integrative Biology (IN)
- Max Super Speciality Hospital (IN)
- Max Healthcare (IN)
- Ashoka University (IN)
- Indian Institute of Technology Delhi (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2024-10-17
- DOI
- https://doi.org/10.1371/journal.pntd.0012589
- Citations
- 6
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 3.26
Funders
- Bill and Melinda Gates Foundation
- Rockefeller Foundation