Amyloid-β predominant Alzheimer’s disease neuropathologic change

Different subsets of Alzheimer's disease neuropathologic change (ADNC), including the intriguing set of individuals with severe/widespread amyloid-β (Aβ) plaques but no/mild tau tangles [Aβ-predominant (AP)-ADNC], may have distinct genetic and clinical features. Analysing National Alzheimer's Coordinating Center data, we stratified 1187 participants into AP-ADNC (n = 95), low Braak primary age-related tauopathy (PART; n = 185), typical-ADNC (n = 832) and high-Braak PART (n = 75). AP-ADNC differed in some clinical features and genetic polymorphisms in the APOE, SNX1, WNT3/MAPT and IGH genes. We conclude that AP-ADNC differs from classical ADNC with implications for in vivo studies.

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Journal
Brain
Published
2024-10-17
DOI
https://doi.org/10.1093/brain/awae325
Citations
9
Primary Topic
Alzheimer's disease research and treatments
Type
article
Field-Weighted Citation Impact
2.94

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article

Amyloid-β predominant Alzheimer’s disease neuropathologic change

Arjun V. Masurkar, Sandra Weıntraub, Ronald L. Hamilton, Roger L. Albin et al.
9 citations
Brain
Alzheimer's disease research and treatments
2.94
article

Amyloid-β predominant Alzheimer’s disease neuropathologic change

Arjun V. Masurkar, Sandra Weıntraub, Ronald L. Hamilton, Roger L. Albin, Scott Chasse, Lawrence S. Honig, Joseph E. Parisi, Kirk C. Wilhelmsen, Matthew P. Frosch, James R. Burke, Marcia G. Ory, John Olichney, Dennis W. Dickson, Mary Sano, Gábor G. Kovács, Gayle Ayres, Ekaterina A. Rogaeva, Elaine R. Peskind, Marie‐Françoise Chesselet, Daniel H. Geschwind, Suzanne Craft, Adam L. Boxer, Otto Valladares, Jonathan L. Haines, John Hardy, Randall L. Woltjer, Gary W. Beecham, Peter T. Nelson, Raymond F. Palmer, Neil W. Kowall, Marilyn Albert, Allan I. Levey, Barb Davis, Linda J. Van Eldik, Salvatore Spina, Yuriko Katsumata, Stephen M. Strittmatter, Andrew J. Saykin, Helena Chui, Frank M. LaFerla, Lisa L. Barnes, Trung Nguyen, Robert Vassar, Jeffrey L. Tilson, C. Dirk Keene, John Bertelson, Liana G. Apostolova, Gyungah Jun, Robert C. Barber, Ann Carolyn McKee, David L. Sultzer, Joseph D. Buxbaum, Matthew J. Huentelman, Lindsay A. Farrer, Charles DeCarli, Michael L. Cuccaro, Jeffery M. Vance, Kara L. Hamilton‐Nelson, Carlos C Cruchaga, Jeffrey Kaye, Harry V. Vinters, David Paydarfar, Martin Woon, Debby W. Tsuang, Janice Knebl, Valory Pavlik, Linda S. Hynan, Christiane Reitz, Susan M. McCurry, Eric M. Reiman, Bernardino Ghetti, Juan C. Troncoso, Philip L. De Jager, John Malamon, Rudolph E. Tanzi, Huntington Potter, Paul K. Crane, Russell Howard Swerdlow, James D. Bowen, Kim G. Johnson, James B. Leverenz, Henrick Wilms, Marsha Polk, Chuanhai Cao, Adam C. Naj, Henry L. Paulson, Minerva M. Carrasquillo, Shubhabrata Mukherjee, Aisha Khaleeq, Paul J. Massman, Murray A. Raskind, Gail P. Jarvik, Sid E. O’Bryant, Shelley L. Forrest, Thomas Wısnıewskı, Amanda Smith, Marla Gearing, John C. Morris, John C. DeToledo, Yi Zhao, William S. Bush, Jeffrey Murray Burns, Craig Atwood, Peter St George‐Hyslop, Nathaniel A. Chin, Bradley T. Hyman, Robert A. Stern, Elizabeth Head, Martin R. Farlow, Khine Zin Aung, Douglas Mains, Douglas R Galasko, C. Munro Cullum, William W. Seeley, Scott A. Small, Ronald Kim, Roger N. Rosenberg, Nilüfer Ertekin‐Taner, Alyssa Aguirre, Liming Qu, Adriana C. Gamboa, Laura B. Cantwell, Mariet Allen, Erik D. Roberson, M. Ilyas Kamboh, Janet L. Smith, Eden R. Martin, Brian W. Kunkle, Joshua A. Sonnen, Joseph F. Quinn, Kathryn L. Lunetta, Victor W. Henderson, John M. Ringman, David W. Fardo, Ge Li, Håkon Håkonarson, Lorna M. Lopez, Steven Edward Arnold, James T. Becker, Daniel Marson, Benjamin Williams, Alison Goate, Monica Rodriguear, Badri Narayan Vardarajan, Gerard D. Schellenberg, Xian Wu, Bradley F Boeve, Michelle L. Hernandez, Victòria Aurora Ferrer Pérez, Leigh Ann Johnson, Robert C. Green, Lei Yu, Amanda P Kuzma, Joel H. Kramer, Lon S. Schneider, Thomas S. Wingo, Ryan M. Huebinger, Raj Ashok, James Richard Hall, Alan Stevens, Eric B. Larson, Sanjay Asthana, Sandra Barral, Lisa Alvarez, Alan J Lerner, Christine M. Hulette, Thomas Bird, Kelley Faber, James J. Lah, Thomas G. Beach, Neill R Graff-Radford, Richard Mayeux, Eileen H. Bigio, Constantine G. Lyketsos, Steven G. Younkin, Mark A. Sager, Deborah Blacker, Joan Reisch, Clinton T. Baldwin, Li-San Wang, John Kauwe, Tatiana M. Foroud, Ronald C. Petersen, Lee‐Way Jin, Marsel Mesulam, Carol A. Miller, James Brewer, John Q. Trojanowski, Kenneth B. Fallon, Thomas J. Montine, Vivianna M Van Deerlin, Anna Karydas, Donald R. Royall, Howard J. Rosen, John R. Gilbert, Perrie M. Adams, Jennifer Williamson, Mindy Joy Katz, Ranjan Duara, Edwin S. Monuki, Nigel J Cairns, Eveleen Darby, Richard Lipton, Amanda Myers, Wayne C. McCormick, Andrew P. Lieberman, Regina M. Carney, Kathleen A. Welsh‐Bohmer, Denis A. Evans, Mary Quiceno, Cynthia M. Carlsson, Thomas Fairchild, John H. Growdon, Bruce L. Miller, Xiongwei Zhou, Lindy E. Harrell, Jean Paul Vonsattel, Chang‐en Yu, Margaret A Pericak‐Vance, Thomas Grabowsk
article en
9 citations

Abstract

Different subsets of Alzheimer's disease neuropathologic change (ADNC), including the intriguing set of individuals with severe/widespread amyloid-β (Aβ) plaques but no/mild tau tangles [Aβ-predominant (AP)-ADNC], may have distinct genetic and clinical features. Analysing National Alzheimer's Coordinating Center data, we stratified 1187 participants into AP-ADNC (n = 95), low Braak primary age-related tauopathy (PART; n = 185), typical-ADNC (n = 832) and high-Braak PART (n = 75). AP-ADNC differed in some clinical features and genetic polymorphisms in the APOE, SNX1, WNT3/MAPT and IGH genes. We conclude that AP-ADNC differs from classical ADNC with implications for in vivo studies.

BrainVol. 148(2)
University Health Network (CA), University of Kentucky (US), University of Toronto (CA), Occupational Cancer Research Centre (CA)
U.S. Department of Defense, Foundation for the National Institutes of Health, U.S. Department of Veterans Affairs, Alzheimer's Association, Bristol-Myers Squibb, Eli Lilly and Company, Pfizer, Massachusetts General Hospital, Biogen, University of Southern California, Office of Research and Development, Vanderbilt University, University of Miami, University of Pennsylvania, Emory University, Meso Scale Diagnostics, Northwestern University, BioClinica, University of Washington, Johns Hopkins University, University of Pittsburgh, Novartis Pharmaceuticals Corporation, Rush University, Northern California Institute for Research and Education, Wellcome Trust, Alzheimer's Research Trust, York University, Newcastle University, Stichting MS Research, Eisai, North Bristol NHS Trust, Universitat de Barcelona, Hersenstichting, Servier, H. Lundbeck A/S, IXICO, National Institutes of Health, Genentech, University of California, Los Angeles, University of California, San Diego, University of California, San Francisco, Canadian Institutes of Health Research, Medical Research Council, National Institute on Aging, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke
Good health and well-being
Openalex Percentile: Top 8%
Alzheimer's disease research and treatments
2.94
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