Population pharmacokinetics/pharmacodynamics of minocycline plus rifampicin in patients with complicated skin and skin structure infections caused by MRSA
Population PK models of minocycline, rifampicin and linezolid were developed in patients with MRSA cSSTI and almost all patients reached the predefined PD index targets. As a result, neither AUC, MIC nor the AUC/MIC ratio could be related to clinical outcome.
Authors
- Mark Bayliss
- Evangelos J. Giamarellos‐Bourboulis (ORCID: https://orcid.org/0000-0003-4713-3911)
- Karen E. Bowker
- Andrew Lovering (ORCID: https://orcid.org/0000-0002-7573-3220)
- Sònia Luque (ORCID: https://orcid.org/0000-0002-3215-320X)
- Antigone Kotsaki (ORCID: https://orcid.org/0000-0002-6345-4021)
- Rebecca Evans (ORCID: https://orcid.org/0000-0002-7119-8187)
- William Hope (ORCID: https://orcid.org/0000-0001-6187-878X)
- Alasdair MacGowan (ORCID: https://orcid.org/0000-0002-6720-5268)
- Shampa Das (ORCID: https://orcid.org/0000-0002-2540-4816)
- Karolina Akinosoglou (ORCID: https://orcid.org/0000-0002-4289-9494)
- Marie Attwood (ORCID: https://orcid.org/0000-0003-1047-2098)
- Alan Noel
- Miriam O’Hare
- Theano Kontopoulouk
Institutions
- Micron (United States) (US)
- North Bristol NHS Trust (GB)
- University of Liverpool (GB)
- University of Patras (GR)
- National and Kapodistrian University of Athens (GR)
- Southmead Hospital (GB)
- University of Bristol (GB)
- Parc de Salut (ES)
- Evangelismos Hospital (GR)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1093/jac/dkae363
- Citations
- 3
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Pfizer
- National Institute for Health and Care Research
- National and Kapodistrian University of Athens
- Shionogi
- Angelini Pharma
- Swedish Orphan Biovitrum
- Seventh Framework Programme
- HORIZON EUROPE Framework Programme
- Medical Research Council