Gluconeogenesis and glycogenolysis required in metastatic breast cancer cells
Our results indicate that increased glycogen accumulation is primarily mediated through the gluconeogenesis pathway and that glycogen utilization is required for both migration and ECM detached survival of metastatic MCF10CA1a cells. These results suggest that glycogen metabolism may play an important role in the progression of breast cancer metastasis.
Authors
- Marjorie Anne Layosa (ORCID: https://orcid.org/0000-0001-5080-0127)
- Chaylen Andolino (ORCID: https://orcid.org/0000-0001-6836-049X)
- Dorothy Teegarden (ORCID: https://orcid.org/0000-0002-7045-3748)
- Timothy D. Heden (ORCID: https://orcid.org/0000-0003-3977-521X)
- Shawn S. Donkin (ORCID: https://orcid.org/0000-0003-3571-4946)
- Emily M. Hicks (ORCID: https://orcid.org/0000-0001-9102-9244)
- Yazhen Song
- Caitlin Truffer
Institutions
- Pennington Biomedical Research Center (US)
- Oregon State University (US)
- Purdue University West Lafayette (US)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2024-10-16
- DOI
- https://doi.org/10.3389/fonc.2024.1476459
- Citations
- 2
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.57