Back pain exercise therapy remodels human epigenetic profiles in buccal and human peripheral blood mononuclear cells: an exploratory study in young male participants
This pre-post cohort study highlights the potential of integrated molecular profiles to score therapy efficiency. Our findings reflect the complex interplay of an individual's background and lifestyle upon therapeutic exposure. Future studies are needed to provide mechanistic insights into back pain pathogenesis and lifestyle-based epigenetic reprogramming upon sport therapy intervention to maintain therapeutic effects in the long run.
Authors
- Mia Potočnjak (ORCID: https://orcid.org/0000-0002-6157-7300)
- Michael Hollmann (ORCID: https://orcid.org/0000-0002-2209-2773)
- Claire Burny (ORCID: https://orcid.org/0000-0002-0279-3812)
- Moritz Voelker-Albert
- Victor Solis‐Mezarino (ORCID: https://orcid.org/0000-0002-5766-7418)
- Frank Schifferdecker-Hoch
- Simone Di Sanzo
- Annika Hestermann
- Sophie Gartemann
- Nina Markanovic
- Michael Günsel
Institutions
- Zentrum für Pathologie und Zytodiagnostik (DE)
Publication Details
- Journal
- Frontiers in Sports and Active Living
- Published
- 2024-10-16
- DOI
- https://doi.org/10.3389/fspor.2024.1393067
- Citations
- 1
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.23