The impact of immune dysregulation on the risk of malignancy in common variable immunodeficiency: insights from a multicenter study
This study highlights the increased cancer risk in CVID patients, with immune dysregulation, prior immunosuppressant use, elevated IgM levels, and lower CD4 cell counts as conjointly associated. These findings underscore the need for vigilant cancer screening and tailored management strategies in CVID patients to improve outcomes. Future research should focus on elucidating the molecular mechanisms linking immune dysregulation and malignancy in CVID.
Authors
- Pedro Moral (ORCID: https://orcid.org/0000-0001-5072-5892)
- Francesc Puchades Gimeno (ORCID: https://orcid.org/0000-0002-0937-6819)
- Víctor García-Bustos (ORCID: https://orcid.org/0000-0002-1785-258X)
- Alba Canovas Mora
- Miguel Ángel Torralba-Cabeza (ORCID: https://orcid.org/0000-0002-0451-3597)
- Xavier Solanich (ORCID: https://orcid.org/0000-0002-2572-2187)
- Ángel Robles‐Marhuenda (ORCID: https://orcid.org/0000-0003-1156-2570)
- J.L. Patier de la Peña (ORCID: https://orcid.org/0000-0003-3628-2647)
- Carmen Bracke
- Antonia Mora Rufete
- Lourdes Mateu (ORCID: https://orcid.org/0000-0001-7223-7611)
- Daniel L. Wolf (ORCID: https://orcid.org/0000-0003-2480-9907)
- Guillem Pascual Castellanos
- José Manuel Barragán Casas (ORCID: https://orcid.org/0000-0003-2616-8306)
- Rosario Sánchez‐Martínez (ORCID: https://orcid.org/0000-0003-0408-3029)
- Ana María Bielsa Masdeu
- Núria Tornador Gaya
- Ana Pelaez Ballesta
- Nuria López-Osle
- Juan Luis Carrillo-Linares (ORCID: https://orcid.org/0000-0003-0968-3234)
- Andrés González‐García
- Héctor Balastegui-Martín (ORCID: https://orcid.org/0000-0002-4651-6841)
- Marta Dafne Cabañero-Navalón (ORCID: https://orcid.org/0000-0002-1447-9214)
- Jorge Gil Niño
Institutions
- Catholic University of Ávila (ES)
- Hospital Universitario La Paz (ES)
- Bellvitge University Hospital (ES)
- Hospital Universitari i Politècnic La Fe (ES)
- Research Institute Hospital 12 de Octubre (ES)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Hospital Universitario Fundación Alcorcón (ES)
- Hospital Rafael Méndez (ES)
- Hospital Universitario Miguel Servet (ES)
- Hospital General Universitario de Elche (ES)
- Leitat Technological Center (ES)
- Hospital General Universitari de Castelló (ES)
- Instituto Ramón y Cajal de Investigación Sanitaria (ES)
- Hospital General Universitario De Valencia (ES)
- Hospital Clínico Universitario Lozano Blesa (ES)
- Hospital de Cruces (ES)
- Hospital General Universitario de Alicante Doctor Balmis (ES)
- Hospital Universitari Germans Trias i Pujol (ES)
- Hospital Clínico Universitario Virgen de la Victoria (ES)
- Fundació Lluita contra les Infeccions (ES)
- Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL) (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-10-16
- DOI
- https://doi.org/10.3389/fimmu.2024.1465159
- Citations
- 10
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.40
Funders
- CSL Behring
- European Society for Immunodeficiencies