Identifying HIF1A and HGF as two hub genes in aortic dissection and function analysis by integrating RNA sequencing and single-cell RNA sequencing data
By integrating RNA-seq and scRNA-seq data, we identified <i>HIF1A</i> and <i>HGF</i> as two hub genes with good diagnostic efficiency for AD. HIF1A in macrophages may promote AD formation by promoting inflammation, glycolysis, tissue remodeling, and angiogenesis, and HGF may mediate signaling among SMCs, fibroblasts, and endothelial cells in the development of AD.
Authors
- Shuiqiao Yuan (ORCID: https://orcid.org/0000-0003-1460-7682)
- Xin Cong (ORCID: https://orcid.org/0000-0001-5387-1414)
- X. Mao (ORCID: https://orcid.org/0009-0001-3091-6816)
- Chang Liu (ORCID: https://orcid.org/0000-0002-5717-3370)
- Li Li (ORCID: https://orcid.org/0000-0002-4717-1996)
- Haibing Li (ORCID: https://orcid.org/0000-0001-8388-4937)
Institutions
- Peking University (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2024-10-16
- DOI
- https://doi.org/10.3389/fcvm.2024.1475991
- Citations
- 2
- Primary Topic
- Aortic Disease and Treatment Approaches
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Beijing Municipality