Effects of aging on otolith morphology and functions in mice
This study demonstrated the decline in otolith function with age caused by age-related morphological changes. Specifically, when otolith density decreased, inertial force acting on the hair cells decreased, and when the structure of striola collapsed, the function of cross-striolar inhibition decreased, thereby causing a decline in the overall otolith function.
Authors
- Tatsuhide Tanaka (ORCID: https://orcid.org/0000-0002-3373-9093)
- Kazuya Ono (ORCID: https://orcid.org/0000-0002-3857-0055)
- Kouko Tatsumi (ORCID: https://orcid.org/0000-0001-6230-2803)
- Akio Wanaka (ORCID: https://orcid.org/0000-0001-9951-9862)
- Hiroshi Hibino (ORCID: https://orcid.org/0000-0003-0688-1489)
- Tadao Okayasu (ORCID: https://orcid.org/0000-0002-0811-1405)
- Tadashi Kitahara (ORCID: https://orcid.org/0000-0001-9598-6287)
- Tatsuya Katsuno (ORCID: https://orcid.org/0000-0002-0395-4382)
- Taeko Ito (ORCID: https://orcid.org/0000-0002-3680-1024)
- Takefumi Kamakura (ORCID: https://orcid.org/0000-0002-6491-443X)
- Shotaro Harada
- Takao Imai (ORCID: https://orcid.org/0000-0002-1686-6787)
- Keita Ueda
Institutions
- Kyoto University (JP)
- Japan Agency for Medical Research and Development (JP)
- Nara Medical University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2024-10-16
- DOI
- https://doi.org/10.3389/fnins.2024.1466514
- Citations
- 4
- Primary Topic
- Vestibular and auditory disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.99
Funders
- Japan Agency for Medical Research and Development
- Ministry of Education, Culture, Sports, Science and Technology
- Nara Medical University
- Japan Society for the Promotion of Science
- Core Research for Evolutional Science and Technology