Seven New Aconitine‐Type Diterpenoid Alkaloids from the Roots of <i>Aconitum apetalum</i>
Seven new aconitine-type C<sub>19</sub>-diterpenoid alkaloids, apetaldines K-Q (1-7), were isolated from the roots of Aconitum apetalum (Huth) B. Fedtsch. Their structures were established on the basis of extensive spectroscopic analyses (HRESIMS, 1D and 2D NMR). Among them, compounds 1 and 2 possess a unique 2-(E)-(2-methylbut-2-enamido)benzoate moiety at the C-18 position. Furthermore, cytotoxic activities of these diterpenoid alkaloids were also evaluated.
Authors
- Shuai Huang (ORCID: https://orcid.org/0000-0002-5721-5294)
- Jin‐Bu Xu (ORCID: https://orcid.org/0009-0005-4707-5186)
- Yanyan Luo (ORCID: https://orcid.org/0000-0003-0703-5946)
Institutions
- Southwest Jiaotong University (CN)
Publication Details
- Journal
- Chemistry & Biodiversity
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1002/cbdv.202402055
- Primary Topic
- Plant-based Medicinal Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China