Potential role of solid lipid curcumin particle (SLCP) as estrogen replacement therapy in mitigating TDP-43-related neuropathy in the mouse model of ALS disease
Our results showed that Prp-TDP-43<sup>A315T</sup> mice exhibit altered estradiol levels. Moreover, we demonstrated the efficacy of SLCP as an estrogen replacement therapy in mitigating TDP-43-associated disease progression and pathogenesis. These findings suggest that SLCP could be a promising strategy to induce E2 expression for the treatment of ALS and FTLD.
Authors
- Chi‐Chen Huang (ORCID: https://orcid.org/0000-0001-5410-8285)
- Jeffrey K. Huang (ORCID: https://orcid.org/0000-0003-0996-9451)
- Yi-Chao Lee
- Tsung‐I Hsu (ORCID: https://orcid.org/0000-0002-7524-7740)
- Yi-Chen Hsieh
- Pritha Majumder (ORCID: https://orcid.org/0009-0001-4366-8612)
- Cheng Hu (ORCID: https://orcid.org/0000-0001-7075-8616)
- Asmar Ashan
Institutions
- National Health Research Institutes (TW)
- Georgetown University (US)
- Taipei Medical University Hospital (TW)
- Taipei Medical University (TW)
Publication Details
- Journal
- Experimental Neurology
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1016/j.expneurol.2024.114999
- Citations
- 5
- Primary Topic
- Curcumin's Biomedical Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.85
Funders
- Taipei Medical University-Shuang Ho Hospital, Ministry of Health and Welfare