Hermansones A and B: Bioactive naphthazarin congeners from the European crust fungus Hermanssonia centrifuga
Two previously undescribed naphthazarins named hermansones A (1) and B (2), were isolated from the wood-decaying basidiomycete Hermanssonia centrifuga. The study presents the first report of natural products from the species. The structures of the secondary metabolites were elucidated through NMR spectroscopy and mass spectrometry. The absolute configuration of compound 1 was elucidated using TDDFT-ECD calculations. Hermansone B (2) demonstrated moderate inhibitory effects against Chikungunya virus at IC<sub>50</sub> of 55.97 μM, without inducing notable cytotoxicity.
Authors
- Tibor Kurtán (ORCID: https://orcid.org/0000-0002-8831-8499)
- Marc Stadler (ORCID: https://orcid.org/0000-0002-7284-8671)
- Jackson M. Muema (ORCID: https://orcid.org/0000-0002-5713-5067)
- Attila Mándi (ORCID: https://orcid.org/0000-0002-7867-7084)
- Harald Kellner (ORCID: https://orcid.org/0000-0002-0026-2145)
- Sherif S. Ebada (ORCID: https://orcid.org/0000-0002-2753-0031)
- Winnie Chemutai Sum (ORCID: https://orcid.org/0009-0005-7914-9530)
Institutions
- University of Debrecen (HU)
- International University Institute (IHI) Zittau (DE)
- Technische Universität Dresden (DE)
Publication Details
- Journal
- Fitoterapia
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1016/j.fitote.2024.106261
- Citations
- 1
- Primary Topic
- Bioactive Compounds and Antitumor Agents
- Type
- article
- Field-Weighted Citation Impact
- 0.35
Funders
- Alexander von Humboldt-Stiftung
- National Research, Development and Innovation Office