Hepatitis B Virus-KMT2B Integration Drives Hepatic Oncogenic Processes in a Human Gene-edited Induced Pluripotent Stem Cells-derived Model
Our disease model using genetically engineered iPSCs provides the first insight into both the KMT2B function in HCC development and the oncogenic processes by HBV-KMT2B integration. We clarified the novel oncogenic mechanism in HBV-related HCC due to aberrant KMT2B function.
Authors
- Kento Inada (ORCID: https://orcid.org/0000-0002-6367-6396)
- Taro Shimizu (ORCID: https://orcid.org/0000-0002-3788-487X)
- Shun Kaneko (ORCID: https://orcid.org/0000-0003-2660-6580)
- Miyako Murakawa (ORCID: https://orcid.org/0000-0002-0468-4409)
- Mina Nakagawa (ORCID: https://orcid.org/0000-0003-1608-7676)
- Sei Kakinuma (ORCID: https://orcid.org/0000-0003-2193-5203)
- Mamoru Watanabe (ORCID: https://orcid.org/0000-0002-5475-9544)
- Fukiko Kawai-Kitahata
- Akihide Kamiya (ORCID: https://orcid.org/0000-0002-2552-4236)
- Tomohiro Mochida
- Ryuichi Okamoto (ORCID: https://orcid.org/0000-0002-7047-571X)
- Jun Tsuchiya (ORCID: https://orcid.org/0000-0001-9581-5840)
- Keiya Watakabe
- Yasuhiro Asahina (ORCID: https://orcid.org/0000-0002-9900-0064)
- Sayuri Nitta
- Ayako Sato (ORCID: https://orcid.org/0000-0002-6387-2311)
- Masato Miyoshi
- Rion Kamimae
Institutions
- Tokyo Institute of Technology (JP)
- Tokai University (JP)
- Tokyo University of Science (JP)
- Juntendo University (JP)
- Tokyo Institute of Psychiatry (JP)
- Tokyo Metropolitan Institute of Medical Science (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1016/j.jcmgh.2024.101422
- Citations
- 5
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.93
Funders
- Japan Agency for Medical Research and Development
- Sysmex Corporation
- Japan Society for the Promotion of Science