Transient High Salt Intake Promotes T-Cell–Mediated Hypertensive Vascular Injury
Our data suggest that transient HS intake induces a subclinical T-cell-mediated aortic immune response, which is enhanced by Ang II. We propose a 2-hit model, in which HS acts as a predisposing factor to enhance hypertension-induced T<sub>H</sub>17 and T<sub>C</sub>1 polarization and aortic disease.
Authors
- Sophia Reidel (ORCID: https://orcid.org/0000-0003-4918-857X)
- Denada Arifaj (ORCID: https://orcid.org/0009-0004-2759-6999)
- Sebastian Temme (ORCID: https://orcid.org/0000-0002-8807-2767)
- Milena Feige
- Christina Alter (ORCID: https://orcid.org/0009-0007-8608-2033)
- Lydia Hering
- Johannes Stegbauer (ORCID: https://orcid.org/0000-0001-8994-8102)
- Rianne Nederlof (ORCID: https://orcid.org/0000-0003-4983-464X)
- Mina Yakoub (ORCID: https://orcid.org/0009-0002-3405-2864)
- Marta Kantauskaitė
- Ulrich Flögel (ORCID: https://orcid.org/0000-0001-7181-4392)
- Doron Argov
- Jaroslawna Meister (ORCID: https://orcid.org/0000-0003-4634-1815)
- Jasmina Hoffe (ORCID: https://orcid.org/0009-0005-6433-9219)
- Lars Christian Rump (ORCID: https://orcid.org/0000-0003-0714-6910)
- Markus Kleinewietfeld (ORCID: https://orcid.org/0000-0002-2832-3149)
- Jonathan Jantsch (ORCID: https://orcid.org/0000-0001-6944-2913)
- Dominik N. Müller (ORCID: https://orcid.org/0000-0003-3650-5644)
- Pascal Bouvain (ORCID: https://orcid.org/0000-0002-9116-1330)
- Patricia Kleimann (ORCID: https://orcid.org/0009-0009-8917-4229)
- Masudur Rahman (ORCID: https://orcid.org/0009-0006-9429-6405)
- Jennifer Isabel Kluczny
Institutions
- University of Cologne (DE)
- Max Delbrück Center (DE)
- Humboldt-Universität zu Berlin (DE)
- Düsseldorf University Hospital (DE)
- German Centre for Cardiovascular Research (DE)
- VIB-UGent Center for Inflammation Research (BE)
- Institute of Medical Microbiology and Hygiene (DE)
- Deutsches Diabetes-Zentrum e.V. (DE)
- German Center for Diabetes Research (DE)
- Heinrich Heine University Düsseldorf (DE)
- Hasselt University (BE)
Publication Details
- Journal
- Hypertension
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1161/hypertensionaha.124.23115
- Citations
- 8
- Primary Topic
- Sodium Intake and Health
- Type
- article
- Field-Weighted Citation Impact
- 2.48