Extracellular RIPK3 Acts as a Damage-Associated Molecular Pattern to Exaggerate Cardiac Ischemia/Reperfusion Injury
We identified the positive relationship between plasma RIPK3 concentrations and the risk of major adverse cardiovascular events in patients with acute myocardial infarction receiving PCI. As a damage-associated molecular pattern, extracellular RIPK3 plays a causal role in multiple pathological conditions during cardiac I/R injury through RAGE/CaMKII signaling. These findings expand our understanding of the physiological and pathological roles of RIPK3, and also provide a promising therapeutic target for myocardial I/R injury and the associated complications.
Authors
- Yueshen Sun (ORCID: https://orcid.org/0000-0002-8757-1417)
- Yingjia Li (ORCID: https://orcid.org/0000-0002-8885-2317)
- Jiaxin Duanmu
- Kai Zhang (ORCID: https://orcid.org/0000-0002-2558-0676)
- C F Liu
- Zhuang Tian (ORCID: https://orcid.org/0000-0003-1140-4062)
- Xiangming Fang (ORCID: https://orcid.org/0000-0001-9922-8977)
- Xuya Kang (ORCID: https://orcid.org/0000-0002-6593-5347)
- Haibao Shang
- Xiaomeng Cui (ORCID: https://orcid.org/0000-0003-4942-8246)
- Ye Jin (ORCID: https://orcid.org/0000-0001-6929-5976)
- Xiaolu Shi (ORCID: https://orcid.org/0000-0002-5351-0894)
- Yuanqiang Zhang (ORCID: https://orcid.org/0000-0002-4592-4966)
- Erdan Dong (ORCID: https://orcid.org/0009-0006-8737-5308)
- Nan Li (ORCID: https://orcid.org/0000-0003-4231-8853)
- Jin Li (ORCID: https://orcid.org/0000-0001-9201-2321)
- Kai Wang (ORCID: https://orcid.org/0000-0001-9705-6366)
- Yan Zhang (ORCID: https://orcid.org/0000-0002-8322-467X)
- Peng Xie (ORCID: https://orcid.org/0000-0002-0081-6048)
- Wenjia Zhang (ORCID: https://orcid.org/0000-0002-9299-6137)
- Zeyuan Wang (ORCID: https://orcid.org/0000-0002-8384-2574)
- Yahan Liu (ORCID: https://orcid.org/0000-0002-5948-4615)
- Xiaomin Hu (ORCID: https://orcid.org/0000-0002-5921-1051)
- Junxia Zhang (ORCID: https://orcid.org/0000-0001-7841-8675)
- Yue Wu (ORCID: https://orcid.org/0000-0002-0084-2510)
- Jingli Yang (ORCID: https://orcid.org/0009-0007-1250-8345)
- Wen Zheng (ORCID: https://orcid.org/0000-0001-6451-4770)
- Ting Li (ORCID: https://orcid.org/0000-0003-1377-8076)
- Huilin Qu
- Rui Ma (ORCID: https://orcid.org/0009-0003-5909-593X)
- Xiaozhen Zhuo (ORCID: https://orcid.org/0000-0002-9858-8409)
- Ying Peng (ORCID: https://orcid.org/0000-0002-8801-5711)
- Zhenyu Liu (ORCID: https://orcid.org/0000-0001-5077-5777)
Institutions
- Qingdao University (CN)
- IHI Corporation (United States) (US)
- Dalian Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Peking Union Medical College Hospital (CN)
- World Wide Web Consortium (US)
- Affiliated Hospital of Qingdao University (CN)
- Qingdao Municipal Hospital (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- First Affiliated Hospital of Dalian Medical University (CN)
- China Academy of Chinese Medical Sciences (CN)
- Peking University Third Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
Publication Details
- Journal
- Circulation
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1161/circulationaha.123.068595
- Citations
- 28
- Primary Topic
- Cell death mechanisms and regulation
- Type
- article
- Field-Weighted Citation Impact
- 6.55