Serum Glial Fibrillary Acidic Protein and Neurofilament Light Chain Levels Reflect Different Mechanisms of Disease Progression under B‐Cell Depleting Treatment in Multiple Sclerosis
Elevated sGFAP and lack of drop in sNfL after BCDT start are associated with increased risk of future PIRA. These findings provide a rationale for combined monitoring of sNfL and sGFAP in pwMS starting BCDT to predict the risk of PIRA, and to use sGFAP as an outcome in clinical trials aiming to impact on MS progressive disease biology. ANN NEUROL 2024.
Authors
- Rosetta Pedotti
- Riccardo Galbusera (ORCID: https://orcid.org/0000-0002-3092-8737)
- Marjolaine Uginet (ORCID: https://orcid.org/0000-0001-5997-7500)
- Marcus D’Souza (ORCID: https://orcid.org/0000-0001-5175-9541)
- Claire Bridel (ORCID: https://orcid.org/0000-0001-7267-7676)
- Eline A.J. Willemse (ORCID: https://orcid.org/0000-0001-9140-4243)
- Björn Tackenberg
- Patrice H. Lalive (ORCID: https://orcid.org/0000-0003-0607-5778)
- Lutz Achtnichts
- Alessandro Cagol (ORCID: https://orcid.org/0000-0002-7703-0553)
- Johannes Lorscheider (ORCID: https://orcid.org/0000-0003-1100-2506)
- Ahmed Abdelhak (ORCID: https://orcid.org/0000-0001-9731-4169)
- Sabine Schaedelin
- Anke Salmen (ORCID: https://orcid.org/0000-0002-4751-299X)
- Claudio Gobbi (ORCID: https://orcid.org/0000-0002-7554-0664)
- Jens Kühle (ORCID: https://orcid.org/0000-0002-6963-8892)
- Jannis Müller (ORCID: https://orcid.org/0000-0003-1394-8231)
- Bettina Fischer‐Barnicol (ORCID: https://orcid.org/0009-0000-9369-7238)
- Ludwig Kappos (ORCID: https://orcid.org/0000-0003-4175-5509)
- Robert Hoepner (ORCID: https://orcid.org/0000-0002-0115-7021)
- Andreas Buser (ORCID: https://orcid.org/0000-0002-7942-6746)
- Giulio Disanto (ORCID: https://orcid.org/0000-0002-8512-6096)
- Amandine Mathias (ORCID: https://orcid.org/0009-0005-3604-5096)
- Özgür Yaldizli (ORCID: https://orcid.org/0000-0002-0800-4845)
- Andrew Chan
- Catarina Raposo (ORCID: https://orcid.org/0000-0002-1466-1542)
- Michael Khalil (ORCID: https://orcid.org/0000-0002-5350-3328)
- Klaus Berger (ORCID: https://orcid.org/0000-0001-8966-3684)
- David Conen (ORCID: https://orcid.org/0000-0002-2459-5251)
- Tobias J Derfuss (ORCID: https://orcid.org/0000-0001-8656-4250)
- Juan Gómez (ORCID: https://orcid.org/0000-0002-3318-4649)
- Lars G. Hemkens (ORCID: https://orcid.org/0000-0002-3444-1432)
- Chiara Zecca (ORCID: https://orcid.org/0000-0002-9990-3431)
- Renaud Du Pasquier (ORCID: https://orcid.org/0000-0002-2786-3434)
- Marco Hermesdorf (ORCID: https://orcid.org/0000-0003-3541-7212)
- David Leppert (ORCID: https://orcid.org/0000-0001-6172-801X)
- Pascal Benkert (ORCID: https://orcid.org/0000-0001-6525-8174)
- Caroline Pot (ORCID: https://orcid.org/0000-0002-1146-3129)
- Fredrik Piehl (ORCID: https://orcid.org/0000-0001-8329-5219)
- Oliver Findling (ORCID: https://orcid.org/0000-0003-4298-4370)
- Aleksandra Maleska Maceski (ORCID: https://orcid.org/0000-0002-1916-5927)
- Johanna Oechtering (ORCID: https://orcid.org/0000-0001-5359-7961)
- Cristina Granziera (ORCID: https://orcid.org/0000-0002-4917-8761)
- Edoardo Galli (ORCID: https://orcid.org/0000-0002-9760-2643)
- Jorge R. Oksenberg (ORCID: https://orcid.org/0000-0002-3613-9544)
- Lester Melie‐García (ORCID: https://orcid.org/0000-0001-5602-8916)
- Suvitha Subramaniam
- Heinz Wiendl (ORCID: https://orcid.org/0000-0001-5509-1075)
- David Brassat (ORCID: https://orcid.org/0000-0001-6430-305X)
- Patrick Roth
- Stefanie Müller
- Amar Zadic
Institutions
- University of Geneva (CH)
- Roche (Switzerland) (CH)
- University of Bern (CH)
- Novartis (Switzerland) (CH)
- Karolinska University Hospital (SE)
- Philipps University of Marburg (DE)
- University of California, San Francisco (US)
- University of Basel (CH)
- Swiss Red Cross (CH)
- Medical University of Graz (AT)
- University of Zurich (CH)
- University of St.Gallen (CH)
- University of Münster (DE)
- Kantonsspital St. Gallen (CH)
- University Hospital of Bern (CH)
- University Hospital of Basel (CH)
- Population Health Research Institute (CA)
- Karolinska Institutet (SE)
- Sorbonne Université (FR)
- Laboratory for Biomedical Neurosciences (CH)
- University Hospital of Zurich (CH)
- University Hospital Münster (DE)
- University Hospital of Geneva (CH)
- Pitié-Salpêtrière Hospital (FR)
- Stockholm Health Care Services (SE)
- St. Josef-Hospital (DE)
- Kantonsspital Aarau (CH)
- Università della Svizzera italiana (CH)
- Ruhr University Bochum (DE)
- University of Lausanne (CH)
- McMaster University (CA)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1002/ana.27096
- Citations
- 34
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 14.45
Funders
- National Science Foundation
- Bristol-Myers Squibb
- Biogen
- Universität Basel
- International Progressive MS Alliance
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung