Circulating Baseline <scp>CXCR3</scp><sup>+</sup>Th2 and Th17 Cell Proportions Correlate With Trabecular Bone Loss After 48 Weeks of Biological Treatment in Early Rheumatoid Arthritis
MTX together with bDMARDs efficiently reduce disease activity but only prevent bone loss in a subset of patients with RA after 48 weeks of treatment. The correlations of circulating baseline T helper cell and regulatory T cell populations with trabecular bone changes suggest a potential novel role for these cells in systemic bone homeostasis during early RA.
Authors
- Espen Andre Haavardsholm (ORCID: https://orcid.org/0000-0002-1427-4745)
- Catharina Lindholm
- Ronald van Vollenhoven (ORCID: https://orcid.org/0000-0001-6438-8663)
- Gerður Gröndal (ORCID: https://orcid.org/0009-0009-6751-3330)
- Julia M. Scheffler (ORCID: https://orcid.org/0000-0002-4221-909X)
- Kristina Lend (ORCID: https://orcid.org/0000-0001-5037-5546)
- Till Uhlig (ORCID: https://orcid.org/0000-0002-6881-9552)
- Anna‐Karin Hultgård Ekwall (ORCID: https://orcid.org/0000-0001-8236-6089)
- Christina Drevinge (ORCID: https://orcid.org/0000-0002-6442-1328)
- Kim Hørslev‐Petersen (ORCID: https://orcid.org/0000-0002-5475-7610)
- Dan Nordström
- Björn Guðbjörnsson (ORCID: https://orcid.org/0000-0003-4631-6505)
- Merete Lund Hetland (ORCID: https://orcid.org/0000-0003-4229-6818)
- Michael Twahier Nurmohamed (ORCID: https://orcid.org/0000-0002-6274-1934)
- Mikkel Østergaard (ORCID: https://orcid.org/0000-0003-3690-467X)
- Jon Lampa (ORCID: https://orcid.org/0000-0002-7856-3968)
- Anna Rudin (ORCID: https://orcid.org/0000-0002-4137-1276)
- Mattias Lorentzon (ORCID: https://orcid.org/0000-0003-0749-1431)
- Ulrika Islander (ORCID: https://orcid.org/0000-0002-8493-1739)
- Hans Carlsten (ORCID: https://orcid.org/0000-0002-9321-5152)
- Marte Schrumpf Heiberg (ORCID: https://orcid.org/0000-0003-1104-7755)
- Inger Gjertsson (ORCID: https://orcid.org/0000-0002-9301-4844)
- Tuulikki Sokka‐Isler
Institutions
- University of Copenhagen (DK)
- Karolinska University Hospital (SE)
- University of Iceland (IS)
- University of Eastern Finland (FI)
- University of Southern Denmark (DK)
- University of Oslo (NO)
- Sahlgrenska University Hospital (SE)
- Glostrup Hospital (DK)
- Rigshospitalet (DK)
- Karolinska Institutet (SE)
- Reade (NL)
- National University Hospital of Iceland (IS)
- Diakonhjemmet Hospital (NO)
- Central Finland Health Care District (FI)
- Australian Catholic University (AU)
- University of Gothenburg (SE)
Publication Details
- Journal
- ACR Open Rheumatology
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1002/acr2.11742
- Citations
- 1
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Vetenskapsrådet
- Sahlgrenska Universitetssjukhuset
- Novo Nordisk Foundation Center for Basic Metabolic Research