In silico-driven identification of Pranlukast as a Stabilizer of PD-L1 Homodimers
Our results suggest that pranlukast inhibits the PD-1/PD-L1 axis, meriting its repurposing as an antitumor drug.
Authors
- Alexis Paulina Jiménez‐Uribe (ORCID: https://orcid.org/0000-0002-1620-0416)
- Nohemí Salinas-Jazmín (ORCID: https://orcid.org/0000-0002-9870-8650)
- Zhiqiang An (ORCID: https://orcid.org/0000-0001-9309-2335)
- Marco A. Velasco‐Velázquez (ORCID: https://orcid.org/0000-0001-9717-0265)
- Luis Córdova-Bahena (ORCID: https://orcid.org/0000-0003-2666-6559)
- Carlos Landero-Marín
- Xcaret Flores-Hernández
- Leonardo Daniel Alvarez-Coronel
Institutions
- Brown Foundation (US)
- Secretaría de Ciencia, Humanidades, Tecnología e Innovación (MX)
- Universidad Nacional Autónoma de México (MX)
Publication Details
- Journal
- Anti-Cancer Agents in Medicinal Chemistry
- Published
- 2024-10-16
- DOI
- https://doi.org/10.2174/0118715206303675241009104647
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00