DNA damage and cell death in human oral squamous cell carcinoma cells: The potential biological effects of cannabidiol
CBD inhibits oral cancer growth causing DNA damage. In general, induced cell cytotoxicity appears to be dose- and time-related. Doses of CBD ≥25 μM showed a high reduction in viability. CBD could possibly represent a new therapeutic molecule for its cytotoxic effects against oral squamous cell carcinoma. The mechanism involved in the suppressive effect caused by CBD needs further investigation.
Authors
- Stefano Pagano (ORCID: https://orcid.org/0000-0002-7256-090X)
- Gian Luca Pancrazi
- Stefano Bruscoli (ORCID: https://orcid.org/0000-0003-0313-1615)
- Alessandro Di Michele (ORCID: https://orcid.org/0000-0002-0357-2608)
- F Grignani (ORCID: https://orcid.org/0000-0003-0563-5673)
- Chiara Valenti (ORCID: https://orcid.org/0000-0002-7728-9135)
- Marta Febo (ORCID: https://orcid.org/0009-0000-9874-3547)
- Lorella Marinucci (ORCID: https://orcid.org/0000-0003-0997-3426)
- Monia Billi (ORCID: https://orcid.org/0000-0002-5284-7380)
Institutions
- University of Padua (IT)
- University of Perugia (IT)
Publication Details
- Journal
- Archives of Oral Biology
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1016/j.archoralbio.2024.106110
- Citations
- 8
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 3.58