Synthesis of Novel Indolyl Aryl Sulfone-clubbed Hydrazone Derivatives as Potential HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Molecular Modeling and QSAR Studies
In summary, the synthesized Indolyl Aryl Sulfones, particularly compounds 23, 24, and 28, demonstrate significant potential as Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) against HIV. These results highlight the promising role of these compounds in developing novel NNRTIs for managing HIV infections.
Authors
- Manzoor Ahmad (ORCID: https://orcid.org/0000-0001-9736-5900)
- Hazrat Ali (ORCID: https://orcid.org/0000-0003-3058-5794)
- Abdul Latif (ORCID: https://orcid.org/0000-0002-9047-7747)
- Mumtaz Ali (ORCID: https://orcid.org/0000-0001-7573-7953)
- Muhammad Waqas (ORCID: https://orcid.org/0000-0001-6115-9689)
- Ajmal Khan (ORCID: https://orcid.org/0000-0001-7851-6080)
- Asaad Khalid
Institutions
- University of Nizwa (OM)
- University of Malakand (PK)
- Jazan University (SA)
Publication Details
- Journal
- Current Medicinal Chemistry
- Published
- 2024-10-16
- DOI
- https://doi.org/10.2174/0109298673318987240926052450
- Citations
- 1
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.25