Synthesis of 2,4-bis(trifluoromethyl)benzaldehyde Hybrid Thiosemicarbazones as Prolyl Oligopeptidase Inhibitors for Neurodegenerative Disorders and their In silico Analysis
Moreover, molecular docking depicted a noticeable role of thiosemicarbazide moiety in the binding of these molecules within the active site of the POP enzyme.
Authors
- Muhammad Moazzam Naseer (ORCID: https://orcid.org/0000-0003-2788-2958)
- Sobia Ahsan Halim (ORCID: https://orcid.org/0000-0001-8526-7799)
- Anam Rubbab Pasha
- Naeem Ullah (ORCID: https://orcid.org/0000-0002-1428-8557)
- Ajmal Khan (ORCID: https://orcid.org/0000-0002-2415-7534)
- Ahmed Al‐Harrasi (ORCID: https://orcid.org/0000-0002-0815-5942)
- Zahid Shafiq (ORCID: https://orcid.org/0000-0003-4088-8297)
- Waleed Eltantawy
- Javid Hussain (ORCID: https://orcid.org/0000-0002-2696-1163)
Institutions
- Quaid-i-Azam University (PK)
- Bahauddin Zakariya University (PK)
- Battelle (US)
- Damanhour University (EG)
- University of Nizwa (OM)
- Batterjee Medical College
- King Khalid University (SA)
Publication Details
- Journal
- Current Medicinal Chemistry
- Published
- 2024-10-16
- DOI
- https://doi.org/10.2174/0109298673325023240909101327
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00