Effective Components and Molecular Mechanism of Biejiaruangan Capsule Against Liver Fibrosis: High-resolution Mass Spectrometry, Network Pharmacological Analysis and Experimental Verification
BJRGC can inhibit the proliferation of HSCs by targeting the protein expression of CDK2, CDK6, and PIK3CG in the PI3K/AKT signaling pathway through its prototype components, such as hyperoside, tumulosic acid, and hederagenin, thereby alleviating LF disease.
Authors
- Kefeng Cao (ORCID: https://orcid.org/0009-0005-3417-7116)
- Hui Jiang (ORCID: https://orcid.org/0000-0003-2183-9430)
- Fan Chang
- Zhigang Feng (ORCID: https://orcid.org/0000-0002-3879-485X)
- Qun Zhang (ORCID: https://orcid.org/0000-0003-4352-2901)
- Biao Li (ORCID: https://orcid.org/0000-0002-7971-0085)
- Lili Zhang (ORCID: https://orcid.org/0000-0002-8867-8662)
- Liwei Song (ORCID: https://orcid.org/0000-0003-3954-5617)
Institutions
- Anhui University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Combinatorial Chemistry & High Throughput Screening
- Published
- 2024-10-16
- DOI
- https://doi.org/10.2174/0113862073338867240930031800
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00