An immune signature of postoperative cognitive decline: a prospective cohort study
Immune system-wide monitoring of patients over 60 years old undergoing surgery unveiled a peripheral immune signature of POCD. A predictive model built on immunological data collected before surgery demonstrated greater accuracy in predicting POCD compared to known clinical preoperative risk factors, offering a concise list of biomarker candidates to personalize perioperative management.
Authors
- Jakob Einhaus (ORCID: https://orcid.org/0000-0002-3450-4325)
- Kazuo Ando (ORCID: https://orcid.org/0000-0003-1778-1344)
- Raphaël Gaillard (ORCID: https://orcid.org/0000-0002-1297-4369)
- Martin S. Angst (ORCID: https://orcid.org/0000-0002-1550-8136)
- Dyani Gaudillière (ORCID: https://orcid.org/0000-0003-3017-5939)
- Serge Molliex
- Nima Aghaeepour (ORCID: https://orcid.org/0000-0002-6117-8764)
- Brice Gaudillière (ORCID: https://orcid.org/0000-0002-3475-5706)
- Benjamin Choisy (ORCID: https://orcid.org/0000-0001-9873-6232)
- Grégoire Bellan (ORCID: https://orcid.org/0000-0002-8804-8062)
- Tarek Sharshar (ORCID: https://orcid.org/0000-0003-2276-0951)
- Amélie Cambriel (ORCID: https://orcid.org/0000-0002-8402-8363)
- Adam Bonham
- Boris D. Heifets (ORCID: https://orcid.org/0000-0003-1474-0379)
- Franck Verdonk (ORCID: https://orcid.org/0000-0001-7061-5594)
- Dorien Feyaerts (ORCID: https://orcid.org/0000-0002-0795-6625)
- Julien Hédou (ORCID: https://orcid.org/0000-0003-4721-4797)
- David R. Drover (ORCID: https://orcid.org/0000-0001-6633-3295)
- Maximilian Sabayev (ORCID: https://orcid.org/0009-0009-6673-1651)
- Ina A. Stelzer (ORCID: https://orcid.org/0000-0002-9974-4661)
- Fabrice Chrétien
- Ed Ganio
Institutions
- Télécom Paris (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- University of California San Diego (US)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Nord (FR)
- Centre Hospitalier Sainte-Anne (FR)
- Institut de Psychiatrie et Neurosciences de Paris (FR)
- Centre de Recherche Saint-Antoine (FR)
- FHU Neurovasc (FR)
- Institut Polytechnique de Paris (FR)
- Hôpital Tenon (FR)
- Groupe de recherche clinique en anesthésie réanimation médecine périopératoire (FR)
- Stanford University (US)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1097/js9.0000000000002118
- Citations
- 9
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.23