<i>APOE</i> đ4ârelated bloodâbrain barrier breakdown is associated with microstructural abnormalities
Gray matter blood-brain barrier (BBB) permeability is elevated for APOE4 carriers. APOE4-related BBB breakdown appears in the absence of cognitive decline or amyloid. BBB leakage correlates with entorhinal cortex microstructural injury. Associations with microstructure are strongest for amyloid-positive APOE4 carriers.
Authors
- Murray Andrews (ORCID: https://orcid.org/0000-0001-5404-2204)
- Austin AldersonâMyers
- Qian Shen (ORCID: https://orcid.org/0000-0002-0410-9797)
- Amaryllis A. Tsiknia (ORCID: https://orcid.org/0000-0001-5474-5225)
- Charlotte S. Rivera
- Seraphina K. Solders (ORCID: https://orcid.org/0000-0001-6329-987X)
- Curtis Triebswetter (ORCID: https://orcid.org/0000-0002-1008-4880)
- Emilie T. Reas (ORCID: https://orcid.org/0000-0002-4110-5154)
- James B. Brewer
Institutions
- Boston University (US)
- University of Arizona (US)
- University of Phoenix (US)
- University of California San Diego (US)
- Imaging Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1002/alz.14302
- Citations
- 28
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 11.32
Funders
- Brain Research Foundation
- McKnight Foundation
- Evelyn F. McKnight Brain Research Foundation
- National Institute on Aging