The role of leukocytes in cognitive impairment due to long‐term exposure to fine particulate matter: A large population‐based mediation analysis
The pathways leading to the neurotoxic effects of fine particulate matter (PM<sub>2.5</sub>) are poorly understood. We analyzed data from over 66,000 participants using causal pathway analysis. Increased white blood cell (WBC) count mediates the effect of PM<sub>2.5</sub> on cognitive functioning. Monocyte count played a crucial role in this low-pollution setting. Systemic inflammation may contribute to the neurotoxic effects of PM<sub>2.5</sub>.
Authors
- Gabriele Doblhammer (ORCID: https://orcid.org/0000-0001-7746-0652)
- Benjamin Aretz (ORCID: https://orcid.org/0000-0003-0143-0873)
- Michael T. Heneka (ORCID: https://orcid.org/0000-0003-4996-1630)
Institutions
- University of Massachusetts Chan Medical School (US)
- University of Luxembourg (LU)
- University Hospital Bonn (DE)
- German Center for Neurodegenerative Diseases (DE)
- University of Rostock (DE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1002/alz.14320
- Citations
- 3
- Primary Topic
- Air Quality and Health Impacts
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Universitair Medisch Centrum Groningen