Beyond Antibiotics: A Global Perspective on Combating Antimicrobial Resistance Through One Health and Innovative Technologies

Antimicrobial resistance (AMR) is a global problem that has been emerging and threatens much of the progress in modern medicine over the past centuries. Drawing on the One Health methodology, which recognizes the connections between human, animal, and environmental health, this paper considers how the AMR problem is understood from the different angles (“silos”) of the disciplines involved in the fight against AMR and how we can merge different perspectives to find solutions. It explores the main drivers of resistance and the related economic losses, highlighting some of the innovative approaches in the field, such as CRISPR/Cas9 and nanotechnology, and understanding the causes of resistance through an empirical hypothesis that suggests multidimensional ways to tackle the problem collaboratively. Therefore, this paper calls for the international community’s united action to protect health systems and economies at a global level through education and informed use of antimicrobials.