Enhancing radiosensitivity in osteosarcoma via CDKN2C overexpression: A mechanism involving G1 phase arrest mediated by inhibition of CDK4 expression and Thr172 phosphorylation
Our research results indicate that overexpression of CDKN2C enhances radiosensitivity in osteosarcoma through the induction of G1 phase arrest and subsequent apoptosis. G1 phase arrest is mediated by the suppression of CDK4 expression and Thr172 phosphorylation, which consequently affects the expression of phosphorylated RB at the Ser807/811 sites.
Authors
- Peijun Dai
- Bingxuan Wang
- Suchi Qiao
- Qiujian Lian
- Haonan Zhao (ORCID: https://orcid.org/0009-0007-4125-2043)
- Zhiwei Wang (ORCID: https://orcid.org/0000-0001-5643-9344)
- J. Li (ORCID: https://orcid.org/0000-0001-5245-2074)
- Junbo Ge (ORCID: https://orcid.org/0000-0002-9360-7332)
- Xu Su (ORCID: https://orcid.org/0000-0002-5970-8172)
- Ping Ling (ORCID: https://orcid.org/0000-0002-9509-7743)
Institutions
- Second Military Medical University (CN)
- Eastern Hepatobiliary Surgery Hospital (CN)
- Fujian Provincial Hospital (CN)
- First Affiliated Hospital of Bengbu Medical College (CN)
Publication Details
- Journal
- Biochemical and Biophysical Research Communications
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1016/j.bbrc.2024.150840
- Citations
- 1
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.28
Funders
- National Natural Science Foundation of China