Early metabolic and hemodynamic indicators of kidney dysfunction in mice offspring from parental low protein diet
Our findings indicate that significant kidney damage must accumulate in the F1 generation from parents fed an LPD before any detectable changes in blood pressure occur. Our study suggests that small variations in kidney metabolic function may point to early kidney damage and should not be overlooked in the offspring of these malnourished mice and likely humans.
Authors
- Samir S. El‐Dahr (ORCID: https://orcid.org/0000-0001-7571-4292)
- Francesca Edgington-Giordano
- Giovane G. Tortelote (ORCID: https://orcid.org/0000-0002-9312-3442)
- Fabiola Diniz (ORCID: https://orcid.org/0000-0003-3302-0510)
Institutions
- Tulane University (US)
Publication Details
- Journal
- Molecular and Cellular Pediatrics
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1186/s40348-024-00184-8
- Citations
- 2
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 2.22
Funders
- National Institute of Diabetes and Digestive and Kidney Diseases