Anthelmintic Activity of Carica papaya Leaf Extracts: Insights from In Vitro and In Silico Investigations
Molecular docking studies with proteins <i>Ascaris lumbricoides</i> β-tubulin and Trichuris trichiura β-tubulin revealed potential binding interactions of CPLE compounds, notably Hexadecanoic acid, 2-hydroxy-1-(hydroxymethyl) ethyl ester, and Albendazole oxide. Conclusión: These findings suggest the anthelmintic efficacy of CPLE and provide insights into its mode of action at the molecular level.
Authors
- Mohamed A. Dkhil (ORCID: https://orcid.org/0000-0003-1869-5800)
- Jazem A. Mahyoub (ORCID: https://orcid.org/0000-0002-6778-4255)
- Salsabil S. Afifi
- Denis Delić (ORCID: https://orcid.org/0000-0003-0233-8374)
- Rewaida Abdel‐Gaber (ORCID: https://orcid.org/0000-0001-9263-6871)
- Nawal S. Alhaiqi
Institutions
- Ain Shams University (EG)
- Boehringer Ingelheim (Germany) (DE)
- Applied Science Private University (JO)
- King Abdulaziz University (SA)
- King Saud University (SA)
- King Abdul Aziz University Hospital (SA)
- Helwan University (EG)
Publication Details
- Journal
- Combinatorial Chemistry & High Throughput Screening
- Published
- 2024-10-16
- DOI
- https://doi.org/10.2174/0113862073341577240925100048
- Citations
- 5
- Primary Topic
- Papaya Research and Applications
- Type
- article
- Field-Weighted Citation Impact
- 3.58