Design and Development of [1,2,4]Triazolo[4,3-b][1,2,4]triazines as Potential Anticancer Agents with Genotoxicity and Apoptotic Activity
Our results showed that compound 8c significantly increased cell death through apoptosis induction and caused a significant increase in genotoxicity. Furthermore, it was found that the tested compound 8c, with a selectivity index of 1.74, possessed selective antiproliferative activity towards the colorectal cancer cell line HCT-116 compared to the normal fibroblast cell line. These findings could be useful in the development of novel VEGFR2/c-Met dual-targeted inhibitors in the future.
Authors
- Hamid Irannejad (ORCID: https://orcid.org/0000-0001-7513-6162)
- Zahra Zakeri Khatir (ORCID: https://orcid.org/0000-0001-8379-5643)
- Mehdi Valipour (ORCID: https://orcid.org/0000-0001-6689-3743)
- Khaled Rahmani (ORCID: https://orcid.org/0000-0002-0860-8040)
- Majid Ghasemian (ORCID: https://orcid.org/0000-0003-2017-7877)
- Shaghayegh Aghajanshakeri
- Mohammad Shokrzadeh (ORCID: https://orcid.org/0000-0003-4197-6395)
Institutions
- Ahvaz Jundishapur University of Medical Sciences (IR)
- Iran University of Medical Sciences (IR)
- Mazandaran University of Medical Sciences (IR)
Publication Details
- Journal
- Medicinal Chemistry
- Published
- 2024-10-16
- DOI
- https://doi.org/10.2174/0115734064327919240926112444
- Citations
- 2
- Primary Topic
- Synthesis and Characterization of Heterocyclic Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.50