Characterization of small RNAs in the spleen of MASH in a non-human primate model

Metabolic dysfunction-associated steatotic liver disease (MASLD) and its advanced stage, metabolic dysfunction-associated steatohepatitis (MASH), are increasingly recognized as a global health issue. This study examines the role of small RNAs in the spleen of MASH using a non-human primate model. We performed high-throughput small RNA sequencing on spleen tissues from MASH-primates, revealing significant alterations in the expression of small non-coding RNAs, especially miRNAs. Notably, miR-96, miR-182, miR-183, and miR-122 showed differential expression in MASH spleens. Predictive and validation studies have identified potential target genes, such as PTX3 and NFIX, that were significantly dysregulated in spleens of MASH. These findings characterized small RNAs in spleen of MASH and offer a novel insight for further research for MASH.

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Publication Details

Journal
Genomics
Published
2024-10-16
DOI
https://doi.org/10.1016/j.ygeno.2024.110953
Primary Topic
Animal Virus Infections Studies
Type
article
Field-Weighted Citation Impact
0.00

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article

Characterization of small RNAs in the spleen of MASH in a non-human primate model

Enqi Liu, Liangshuo Hu, Ruike Ding, Huijie Leng et al.
Genomics
Animal Virus Infections Studies
article

Characterization of small RNAs in the spleen of MASH in a non-human primate model

Enqi Liu, Liangshuo Hu, Ruike Ding, Huijie Leng, Wenbin Cao, Hongyu Qin, Pengxiang Qu, Liwei Zhang, Bo Wang, Yandong Li, Yanru Zhang, Yun Ye, Yuelei Zhao, Juan Zhao, Chenjing Duan
article en

Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD) and its advanced stage, metabolic dysfunction-associated steatohepatitis (MASH), are increasingly recognized as a global health issue. This study examines the role of small RNAs in the spleen of MASH using a non-human primate model. We performed high-throughput small RNA sequencing on spleen tissues from MASH-primates, revealing significant alterations in the expression of small non-coding RNAs, especially miRNAs. Notably, miR-96, miR-182, miR-183, and miR-122 showed differential expression in MASH spleens. Predictive and validation studies have identified potential target genes, such as PTX3 and NFIX, that were significantly dysregulated in spleens of MASH. These findings characterized small RNAs in spleen of MASH and offer a novel insight for further research for MASH.

GenomicsVol. 116(6)
Medical Center Hospital (US), Xi'an Medical University (CN), First Affiliated Hospital of Xi'an Jiaotong University (CN), Xi'an Jiaotong University (CN)
National Natural Science Foundation of China, Natural Science Foundation of Shaanxi Province
Zero hunger
Openalex Percentile: Top 80%
Animal Virus Infections Studies
DOIOpen Access PDFOpenAlex
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