Cyclin-Dependent Kinase 4/6 Inhibition as a Novel Therapy for Peritoneal Mucinous Carcinomatosis With GNAS Mutations
CDK4/6 inhibition with palbociclib had clinical activity in PMC characterized by mutations in <i>GNAS</i> that was superior to that previously reported with cytotoxic chemotherapy. CDK4/6 inhibition is a novel therapeutic strategy worthy of further evaluation in this subgroup of gastrointestinal neoplasms.
Authors
- Joel Baumgartner (ORCID: https://orcid.org/0000-0001-5381-4751)
- Kaitlyn J. Kelly (ORCID: https://orcid.org/0000-0001-9999-038X)
- Hervé Tiriac (ORCID: https://orcid.org/0000-0001-5039-6750)
- Daisuke Nishizaki (ORCID: https://orcid.org/0000-0002-6746-3224)
- Mojgan Hosseini (ORCID: https://orcid.org/0000-0002-6708-7126)
- Hitendra Patel
- Jula Veerapong (ORCID: https://orcid.org/0000-0002-6124-2586)
- J. Silvio Gutkind (ORCID: https://orcid.org/0000-0002-5150-4482)
- Jonathan Weitz (ORCID: https://orcid.org/0000-0003-0216-7990)
- Jingjing Zou (ORCID: https://orcid.org/0000-0002-4749-105X)
- Juan Rull (ORCID: https://orcid.org/0000-0001-6979-1443)
- Rebekah Ruth White (ORCID: https://orcid.org/0000-0003-2185-8535)
- Gregory P. Botta (ORCID: https://orcid.org/0000-0001-9606-4508)
- Siming Sun (ORCID: https://orcid.org/0000-0003-3037-118X)
- Dana J. Ramms (ORCID: https://orcid.org/0000-0002-7700-1728)
- Joy Liau (ORCID: https://orcid.org/0000-0002-3025-0268)
- Shumei Kato (ORCID: https://orcid.org/0000-0003-1193-1815)
- Andrew M. Lowy (ORCID: https://orcid.org/0000-0002-7106-0735)
- Jay Patel (ORCID: https://orcid.org/0000-0002-3823-6831)
- Isabella Ng (ORCID: https://orcid.org/0009-0004-1277-0421)
- Brian Wishart
Institutions
- University of Wisconsin–Madison (US)
- University of California San Diego (US)
- Human Longevity (United States) (US)
- Moores Cancer Center
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1200/jco.24.00511
- Citations
- 9
- Primary Topic
- Intraperitoneal and Appendiceal Malignancies
- Type
- article
- Field-Weighted Citation Impact
- 5.15