Variants in the N-acetyltranferase 2 gene, acetylator phenotypes and their association with tuberculosis: Findings in Peruvian patients
The A allele, GA heterozygous genotype of the rs1799931 variant of the NAT2 gene, and SA + IA acetylator phenotype showed an association with increased risk for the development of TB. In addition to xenobiotic metabolism, other metabolic and immunological functions of <i>NAT2</i> have also been postulated to confer susceptibility to TB in the Peruvian population owing to its characteristic high Native American component.
Authors
- Teodoro J. Oscanoa (ORCID: https://orcid.org/0000-0001-9379-4767)
- Saul Moscol (ORCID: https://orcid.org/0000-0002-6096-5571)
- María L. Guevara (ORCID: https://orcid.org/0000-0001-5457-231X)
- Ricardo Fujita (ORCID: https://orcid.org/0000-0002-9617-5109)
- Daisy Obispo (ORCID: https://orcid.org/0000-0002-3796-1927)
- Óscar Acosta (ORCID: https://orcid.org/0000-0002-1912-0251)
- Doris Huerta (ORCID: https://orcid.org/0000-0001-5677-8688)
- Lina Laymito
- Rodrigo Sánchez
Institutions
- National University of San Marcos (PE)
- Universidad de San Martín de Porres (PE)
- Hospital Base Guillermo Almenara Irigoyen (PE)
Publication Details
- Journal
- Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1016/j.jctube.2024.100485
- Citations
- 2
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.78
Funders
- Universidad Nacional Mayor de San Marcos
- Fondo Nacional de Desarrollo Científico, Tecnológico y de Innovación Tecnológica
- Fondo Nacional de Desarrollo Científico y Tecnológico