A positive ReceptivaDx result for BCL6 does not correlate with abnormal ERA results or decreased expression of receptivity-associated markers: two sides of the endometrial receptivity coin in fertility evaluation and treatment
A positive ReceptivaDx BCL6 result does not correlate with a prereceptive ERA. Epithelial cells from BCL6-positive endometrium did not show significantly decreased expression in most of the receptivity markers evaluated. These findings demonstrate discordance between the interpretation of "endometrial receptivity" by ReceptivaDx and ERA, and highlight the need for further validation of endometrial evaluation methods in fertility treatment.
Authors
- Ana Almonte-Loya (ORCID: https://orcid.org/0000-0003-2798-3142)
- Hakan Cakmak (ORCID: https://orcid.org/0000-0002-8321-2222)
- Linda C. Giudice (ORCID: https://orcid.org/0000-0002-1677-0822)
- Meagan Chan
- David Huang (ORCID: https://orcid.org/0000-0002-5569-6442)
- Emily Flynn (ORCID: https://orcid.org/0000-0002-0566-9796)
- Juan C. Irwin (ORCID: https://orcid.org/0000-0002-5647-4331)
- Brittany Davidson (ORCID: https://orcid.org/0000-0003-3538-2822)
- Marcelle Ivonne Cedars (ORCID: https://orcid.org/0000-0003-3682-6907)
- Alexis J. Combes (ORCID: https://orcid.org/0000-0002-9110-6542)
- Marina Sirota (ORCID: https://orcid.org/0000-0002-7246-6083)
- Gabriela K. Fragiadakis (ORCID: https://orcid.org/0000-0001-9703-2591)
- Amber Casillas
Institutions
- University of California, San Francisco (US)
- University of California System (US)
- Reproductive Science Center (US)
- University of San Francisco (US)
Publication Details
- Journal
- F&S Science
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1016/j.xfss.2024.10.005
- Citations
- 2
- Primary Topic
- Ovarian function and disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.07
Funders
- National Institute of Child Health and Human Development