First-in-human study of D6-[18F]FP-(+)-DTBZ, a novel VMAT2 tracer: whole-body biodistribution and brain PET comparison with [18F]FP-(+)-DTBZ (AV-133)
D6-[<sup>18</sup>F]FP-(+)-DTBZ is a safe and improved VMAT2-specific imaging agent, which may be suitable for diagnosing PD by evaluating changes in VMAT2 binding of monoamine neurons in the brain. Trial registration Chinese Clinical Trial Registry, ChiCTR2200057218, Registered 16 August 2021, https://www.chictr.org.cn/bin/project/edit?pid=142725 .
Authors
- Ruiyue Zhao (ORCID: https://orcid.org/0000-0001-5242-0785)
- David Alexoff (ORCID: https://orcid.org/0000-0002-0612-1239)
- Karl Plöessl (ORCID: https://orcid.org/0000-0001-7896-5900)
- Hank F. Kung (ORCID: https://orcid.org/0000-0003-3254-8049)
- Lin Zhu
- Ting Ye (ORCID: https://orcid.org/0000-0002-4268-870X)
- Ling Chen (ORCID: https://orcid.org/0000-0002-6909-9606)
- Yan Zhang (ORCID: https://orcid.org/0000-0001-9028-7495)
- Jinhua Chen
- Xinlu Wang (ORCID: https://orcid.org/0000-0003-1997-5687)
- Shaoyu Liu
- Siran Xu
- Jianmin Chu (ORCID: https://orcid.org/0009-0003-1489-1318)
- Jingwen Li (ORCID: https://orcid.org/0009-0000-3382-6341)
Institutions
- Sun Yat-sen University (CN)
- Beijing Normal University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- University of Pennsylvania (US)
- Philadelphia Fight (US)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- EJNMMI Radiopharmacy and Chemistry
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1186/s41181-024-00301-y
- Citations
- 3
- Primary Topic
- Amino Acid Enzymes and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.88
Funders
- Guangzhou Medical University
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province