Atractylodes lancea Rhizome Polysaccharide Alleviates MCD Diet-Induced NASH by Inhibiting the p53/mTOR Pathway
Nonalcoholic steatohepatitis (NASH) is a form of chronic liver disease that is characterized by liver inflammation and steatosis, with possible progression to fibrosis. Currently, no drugs have been approved for the treatment of NASH. In this study, we isolated a polysaccharide from <i>Atractylodes lancea</i> rhizome (AP) and established a methionine- and choline-deficient (MCD) diet -induced NASH mouse model to investigate the preventive effect and potential mechanism of AP on NASH. The results showed that AP effectively reduced liver lipid accumulation and inflammation and reduced autophagy and ferroptosis in hepatocytes, thereby preventing the development of NASH. These findings suggest that AP may be a promising natural candidate for the treatment of NASH.
Authors
- Chuiyang Zheng
- Liang Zheng (ORCID: https://orcid.org/0009-0004-3488-2141)
- Qingliang Song (ORCID: https://orcid.org/0000-0002-2818-6025)
- Dajin Pi (ORCID: https://orcid.org/0000-0002-2805-6458)
- Jianwei Zhen (ORCID: https://orcid.org/0000-0002-1393-2742)
- Maoxing Pan (ORCID: https://orcid.org/0000-0001-5904-4970)
- Qinhe Yang (ORCID: https://orcid.org/0000-0002-8484-6665)
- Jinyue Pan
- Yupei Zhang (ORCID: https://orcid.org/0000-0001-8837-1313)
- Wen Fan
Institutions
- Jinan University (CN)
Publication Details
- Journal
- International Journal of Molecular Sciences
- Published
- 2024-10-16
- DOI
- https://doi.org/10.3390/ijms252011112
- Citations
- 7
- Primary Topic
- Ginseng Biological Effects and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.64
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Guangdong Province
- Jinan University
- Traditional Chinese Medicine Bureau of Guangdong Province
- Fundamental Research Funds for the Central Universities