Synthesis of 6-<i>oxa</i>-Spiro[4.5]decane Derivatives by Merging Ring-Opening of Benzo[<i>c</i>]oxepines and Formal 1,2-Oxygen Migration
A facile one-pot synthetic method has been developed for constructing 6-<i>oxa</i>-spiro[4.5]decane skeletons by merging the ring-opening of benzo[<i>c</i>]oxepines and formal 1,2-oxygen migration reactions. More than 30 examples of the 6-<i>oxa</i>-spiro[4.5]decane derivatives have been synthesized under transition-metal-free conditions.
Authors
- Rongmei Wu (ORCID: https://orcid.org/0000-0001-6033-8124)
- You Zhou (ORCID: https://orcid.org/0009-0007-5054-1875)
- An‐Xin Wu (ORCID: https://orcid.org/0000-0001-7673-210X)
- Yan‐Dong Wu (ORCID: https://orcid.org/0000-0003-0589-7155)
- Dongsheng Yang
- Chun‐Yan Wu (ORCID: https://orcid.org/0009-0004-1347-7972)
- Linlin Ma (ORCID: https://orcid.org/0000-0001-7250-6930)
- Jun-Gang Wang (ORCID: https://orcid.org/0000-0002-1938-3991)
- Yong-Dong Du
- Zhi‐Cheng Yu
Institutions
- Central China Normal University (CN)
- Guizhou Minzu University (CN)
- Ministry of Education (ME)
- State Key Laboratory of Applied Organic Chemistry
- Lanzhou University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1021/acs.joc.4c02206
- Citations
- 2
- Primary Topic
- Axial and Atropisomeric Chirality Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.50
Funders
- National Natural Science Foundation of China
- Guizhou Minzu University
- Department of Education of Guangdong Province
- Higher Education Discipline Innovation Project