Cyano-Fluorosulfonylation of Unactivated Alkenes by Photoredox and Copper Dual Catalysis
Both fluorosulfonyl and cyano groups are important structural motifs in bioactive molecules. Herein, we report a new difunctionalization reaction of alkenes based on fluorosulfonyl radicals, which allows for the introduction of the fluorosulfonyl and cyano groups into unactivated alkenes in one step. This transformation is enabled by merging photoredox and copper catalysis, featuring visible light catalysis, mild conditions, and good functional group tolerance. Further transformation of products via SuFEx reactions is also demonstrated.
Authors
- Rongbiao Wei (ORCID: https://orcid.org/0009-0002-7221-1045)
- Yao Huang (ORCID: https://orcid.org/0000-0003-4088-1300)
- Oleg I. Afanasyev (ORCID: https://orcid.org/0000-0002-6224-6407)
- Saihu Liao (ORCID: https://orcid.org/0000-0002-0251-8757)
- Yuanming Li (ORCID: https://orcid.org/0000-0003-3180-1305)
- Denis Chusov (ORCID: https://orcid.org/0000-0001-6770-5484)
Institutions
- Xiamen University (CN)
- A. N. Nesmeyanov Institute of Organoelement Compounds (RU)
- Fuzhou University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1021/acs.orglett.4c03495
- Citations
- 4
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 1.00
Funders
- National Natural Science Foundation of China
- Russian Science Foundation
- Fuzhou University
- Xiamen University
- Recruitment Program of Global Experts