Exogenous ketones exert antiseizure effects and modulate the gut microbiome and mycobiome in a clinically relevant murine model of epilepsy
Our findings demonstrate that exogenous ketone administration alone can induce antiseizure effects equally via different routes of administration, and that they induce differential shifts in both the bacterial microbiome and mycobiome.
Authors
- Jong M. Rho (ORCID: https://orcid.org/0000-0001-9886-9924)
- G. Campbell Teskey (ORCID: https://orcid.org/0000-0002-8462-355X)
- Mitchell Kesler
- Jane Shearer (ORCID: https://orcid.org/0000-0002-1224-979X)
- Chunlong Mu (ORCID: https://orcid.org/0000-0001-9405-5907)
- Xingyu Chen (ORCID: https://orcid.org/0000-0002-3986-5744)
Institutions
- University of Calgary (CA)
- Alberta Children's Hospital (CA)
- University of California San Diego (US)
- Rady Children's Hospital-San Diego (US)
- Hotchkiss Brain Institute (CA)
Publication Details
- Journal
- Epilepsia
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1111/epi.18150
- Citations
- 3
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.98
Funders
- Alberta Children's Hospital Research Institute
- Canadian Institutes of Health Research