Polyconnectomic Scoring of Functional Connectivity Patterns Across Eight Neuropsychiatric and Three Neurodegenerative Disorders
Our findings reveal generalizable whole-brain connectivity alterations in brain disorders. Polyconnectomic scoring effectively aggregates disorder-related signatures across the entire brain into an interpretable, participant-specific metric. A toolbox is provided for PCS computation.
Authors
- Jackson Tyler Boonstra (ORCID: https://orcid.org/0000-0002-6518-3552)
- Martijn P. van den Heuvel (ORCID: https://orcid.org/0000-0003-1570-1195)
- Marius Gruber (ORCID: https://orcid.org/0000-0002-6094-9950)
- Koen Helwegen (ORCID: https://orcid.org/0000-0002-1247-6626)
- Ilan Libedinsky (ORCID: https://orcid.org/0000-0003-1910-9965)
- Laura Guerrero Simón (ORCID: https://orcid.org/0000-0003-3070-903X)
- Jonathan Repple (ORCID: https://orcid.org/0000-0003-1379-9491)
- Tilo T. J. Kircher (ORCID: https://orcid.org/0000-0002-2514-2625)
- Udo Dannlowski
Institutions
- University of Münster (DE)
Publication Details
- Journal
- Biological Psychiatry
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1016/j.biopsych.2024.10.007
- Citations
- 7
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.40
Funders
- U.S. Department of Defense
- Hearst Foundations
- Alzheimer's Association
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Biogen
- University of Southern California
- Meso Scale Diagnostics
- Alzheimer's Disease Neuroimaging Initiative
- BioClinica
- Novartis Pharmaceuticals Corporation
- Northern California Institute for Research and Education
- Deutsche Forschungsgemeinschaft
- Vrije Universiteit Amsterdam
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Eisai
- Stavros Niarchos Foundation
- Servier
- H. Lundbeck A/S
- Neuraxpharm
- IXICO
- National Institutes of Health
- Genentech
- University of California, San Francisco
- Avid Radiopharmaceuticals
- Canadian Institutes of Health Research
- National Institute of Mental Health