Cinobufotalin inhibits proliferation, migration and invasion in hepatocellular carcinoma by triggering NOX4/NLRP3/GSDMD-dependent pyroptosis
Our study demonstrated that CB suppressed the proliferation, migration, and invasiveness of HCC cells by inducing pyroptosis through the activation of the NOX4/NLRP3/GSDMD signaling pathway. Therefore, our results suggest that CB is a promising therapeutic agent for HCC.
Authors
- Xuanyu Huang (ORCID: https://orcid.org/0000-0003-3613-4740)
- Jianmin Wu (ORCID: https://orcid.org/0000-0002-6526-7967)
- Xianhe Xie (ORCID: https://orcid.org/0000-0002-4134-5887)
- Chen Liu (ORCID: https://orcid.org/0009-0003-0430-6146)
- Zhiwen Li (ORCID: https://orcid.org/0000-0003-2970-5832)
- Yun Huang (ORCID: https://orcid.org/0000-0002-0276-9249)
Institutions
- University of Verona (IT)
- Fujian Medical University (CN)
- Mario Negri Institute for Pharmacological Research (IT)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2024-10-16
- DOI
- https://doi.org/10.3389/fonc.2024.1438306
- Citations
- 5
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Natural Science Foundation of Fujian Province