Engineered Mycobacteriophage TM4::<i>GeNL</i> Rapidly Determines Bedaquiline, Pretomanid, Linezolid, Rifampicin, and Clofazimine Sensitivity in <i>Mycobacterium tuberculosis</i> Clinical Isolates
TM4::GeNL reporter phage DST offers a rapid method to identify M. tuberculosis drug resistance, including resistance to newer tuberculosis drugs.
Authors
- William R. Jacobs (ORCID: https://orcid.org/0000-0003-3321-3080)
- Michelle H. Larsen (ORCID: https://orcid.org/0000-0002-3532-350X)
- Lahari Das (ORCID: https://orcid.org/0000-0002-8951-9532)
- Donna Kohlerschmidt
- Vincent Escuyer (ORCID: https://orcid.org/0000-0002-4435-6709)
- Michael Berney (ORCID: https://orcid.org/0000-0002-4833-0573)
- Amy K. Rourke
- Catherine Vilchèze (ORCID: https://orcid.org/0000-0001-5960-6670)
- Vaishnavi Mahalingam
- Barry Truebody (ORCID: https://orcid.org/0000-0001-7066-3916)
- Emmanuel Asare
- Claire V. Mulholland (ORCID: https://orcid.org/0000-0002-6156-1798)
- Rubeshan Perumal (ORCID: https://orcid.org/0000-0001-8892-2904)
- Senamile L. Ngema (ORCID: https://orcid.org/0000-0003-4355-5068)
- Jared S. Mackenzie (ORCID: https://orcid.org/0000-0002-3089-0900)
- Rajagopalan Saranathan (ORCID: https://orcid.org/0000-0003-2201-8028)
- Adrie J. C. Steyn (ORCID: https://orcid.org/0000-0001-9177-8827)
- Max R. O’Donnell (ORCID: https://orcid.org/0000-0002-1232-3718)
- Sashen Moodley
Institutions
- South African Medical Research Council (ZA)
- New York State Department of Health (US)
- Albert Einstein College of Medicine (US)
- Wadsworth Center (US)
- Columbia University Irving Medical Center (US)
- Centre for the AIDS Programme of Research in South Africa (ZA)
- University of Alabama at Birmingham (US)
- Africa Health Research Institute (ZA)
- University of KwaZulu-Natal (ZA)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1093/infdis/jiae438
- Citations
- 4
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.56
Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases