Paternal metformin use and risk of congenital malformations in offspring in Norway and Taiwan: population based, cross national cohort study
The findings suggest that paternal use of metformin during the period of sperm development is not associated with congenital malformations in offspring, including organ specific malformations. Metformin can therefore continue to be considered a suitable initial oral agent for managing glucose levels in men with type 2 diabetes mellitus who plan on having children.
Authors
- Hui-Min Chuang
- Marleen M. H. J. van Gelder (ORCID: https://orcid.org/0000-0003-4853-4434)
- Fei‐Yuan Hsiao (ORCID: https://orcid.org/0000-0003-1660-9120)
- Lin‐Chieh Meng (ORCID: https://orcid.org/0000-0001-8095-2965)
- Hedvig Nordeng (ORCID: https://orcid.org/0000-0001-6361-2918)
- Liang‐Kung Chen (ORCID: https://orcid.org/0000-0002-2387-8508)
Institutions
- National Yang Ming Chiao Tung University (TW)
- National Taiwan University (TW)
- University of Oslo (NO)
- Taipei Veterans General Hospital (TW)
- National Taiwan University Hospital (TW)
Publication Details
- Journal
- BMJ
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1136/bmj-2024-080127
- Citations
- 10
- Primary Topic
- Prenatal Screening and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 11.09
Funders
- Norges Forskningsråd
- National Science and Technology Council