Collaborative treatment of bone injury with water/acid-reactive nanomotors and photothermal effects
We demonstrate the successful fabrication of a biocompatible nanomotor system for the active delivery of Mg<sup>2+</sup>/H<sub>2</sub> and the promotion of bone fracture healing associated with photothermal effects <i>in vivo</i>. Mg is introduced onto one side of the surface of the single-walled carbon nanotube, functioning as a trigger for the controlled release of Mg<sup>2+</sup>/H<sub>2</sub> by the microenvironment <i>in situ</i>. The asymmetrical release of H<sub>2</sub> is not only the active component that improves the bone repair capability via Mg<sup>2+</sup>/photothermal effects but also the propellant for the motion of the nanomotor. After accumulating at the bone fracture site, the motion of nanomotors can be activated by water/acid, and the active motion further results in enhanced diffusion of Mg<sup>2+</sup>, leading to active therapy for bone injuries with photothermal effects.
Authors
- Lingyan Qiao (ORCID: https://orcid.org/0009-0000-2815-8668)
- Zhenyu Sun (ORCID: https://orcid.org/0000-0001-5788-9339)
- Rui Gao (ORCID: https://orcid.org/0000-0001-5170-6861)
- Weixin Wang (ORCID: https://orcid.org/0000-0001-9008-9990)
- Fei Tong (ORCID: https://orcid.org/0000-0002-5664-5970)
- Yini Wang (ORCID: https://orcid.org/0000-0002-1154-6733)
Institutions
- Binzhou Medical University (CN)
- Shandong University of Aeronautics (CN)
Publication Details
- Journal
- iScience
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1016/j.isci.2024.111190
- Citations
- 3
- Primary Topic
- Micro and Nano Robotics
- Type
- article
- Field-Weighted Citation Impact
- 0.93
Funders
- Natural Science Foundation of Shandong Province
- Binzhou Medical University