Effects of Chitosan and N-Succinyl Chitosan on Metabolic Disorders Caused by Oral Administration of Olanzapine in Mice
Taken collectively, we found that SuChi more than Chi possessed an activity close to that of ORL, preventing metabolic disorders in mice fed with OLZ. As OLZ carries positive charge and SuChi is negatively charged, we hypothesized that SuChi's protective effect can be explained by electrostatic interaction between OLZ byproducts and SuChi in the gastrointestinal tract.
Authors
- В. П. Варламов
- E. V. Svirshchevskaya (ORCID: https://orcid.org/0000-0002-5647-9298)
- В. А. Жуйков (ORCID: https://orcid.org/0000-0003-2852-8002)
- B. Ts. Shagdarova (ORCID: https://orcid.org/0000-0002-6148-7014)
- M. V. Konovalova (ORCID: https://orcid.org/0000-0003-3923-6304)
- V. I. Melnikova (ORCID: https://orcid.org/0000-0003-2851-7039)
- Valentina Kostenko
Institutions
- Russian Academy of Sciences (RU)
- Institute of Bioorganic Chemistry (RU)
- Koltzov Institute of Developmental Biology (RU)
Publication Details
- Journal
- Biomedicines
- Published
- 2024-10-16
- DOI
- https://doi.org/10.3390/biomedicines12102358
- Citations
- 2
- Primary Topic
- Biochemical Analysis and Sensing Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.62
Funders
- Russian Science Foundation