The fatty acid receptor CD36 promotes macrophage infiltration via p110γ signaling to stimulate metastasis
CD36 expands TAM population by promoting the recruitment of circulating monocytes through CCL2/CCR2/p110γ signaling. Our findings provide evidence for targeting CD36 as a therapeutic strategy against liver metastasis.
Authors
- Anhua Xiao
- Xiaoya Zheng (ORCID: https://orcid.org/0000-0002-5288-2119)
- Xiong Z. Ruan (ORCID: https://orcid.org/0000-0001-5199-4971)
- Enze Zheng
- Hong Qin (ORCID: https://orcid.org/0000-0002-4578-5118)
- Wei Li (ORCID: https://orcid.org/0000-0002-7973-6242)
- Huan Liu (ORCID: https://orcid.org/0009-0005-6103-2115)
- Yiyu Li (ORCID: https://orcid.org/0000-0001-8129-1177)
- Chuan Tian (ORCID: https://orcid.org/0000-0002-4825-5032)
- Yaxi Chen (ORCID: https://orcid.org/0000-0002-6242-7152)
- Xiaoqing Luo
- Ping Yang (ORCID: https://orcid.org/0000-0002-0321-1132)
- Qiannan Lu
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- University College London (GB)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1016/j.jare.2024.10.006
- Citations
- 13
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 3.71
Funders
- National Natural Science Foundation of China
- Chongqing Medical University
- Natural Science Foundation of Chongqing
- Chongqing Municipal Education Commission
- Centre Scientifique et Technique du Bâtiment