Altered Spike Immunoglobulin G Fc N-Linked Glycans Are Associated With Hyperinflammatory State in Adult Coronavirus Disease 2019 and Multisystem Inflammatory Syndrome in Children
We identified previously undescribed relationships between spike IgG glycan modifications and inflammatory cytokines/chemokines that expand our understanding of IgG glycosylation changes that may impact COVID-19 and MIS-C immunopathology.
Authors
- Trevor W. Simon (ORCID: https://orcid.org/0000-0001-9930-1011)
- Caroline Ciric
- Brandi Johnson
- Matthew H. Collins (ORCID: https://orcid.org/0000-0001-7974-1933)
- Nadine Rouphael (ORCID: https://orcid.org/0000-0002-2512-7919)
- Erin M. Scherer (ORCID: https://orcid.org/0000-0002-8794-1932)
- Jacob D. Sherman (ORCID: https://orcid.org/0009-0002-2597-7654)
- Sarah Bechnak
- Bhoj Kumar (ORCID: https://orcid.org/0000-0001-8311-7025)
- Anusha Panjwani
- Vinit Karmali
- Parastoo Azadi (ORCID: https://orcid.org/0000-0002-6166-9432)
- Christina A. Rostad (ORCID: https://orcid.org/0000-0001-8439-0592)
- Evan J. Anderson (ORCID: https://orcid.org/0000-0002-1576-4420)
- Dongli Wang (ORCID: https://orcid.org/0000-0002-6704-1646)
- Christopher Huerta
Institutions
- Emory University (US)
- University of Georgia (US)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1093/ofid/ofae626
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- Seoul National University Hospital
- Centers for Disease Control and Prevention
- National Institute of Allergy and Infectious Diseases