A partial loss-of-function variant in STAT6 protects against type 2 asthma
A partial loss-of-function variant in STAT6 resulted in dampened IL-4 responses and protection from T2-high asthma, implicating STAT6 as an attractive therapeutic target.
Authors
- Mie Topholm Bruun (ORCID: https://orcid.org/0000-0002-8819-5388)
- Gísli H. Halldórsson (ORCID: https://orcid.org/0000-0001-7067-9862)
- Bjarni V. Halldórsson (ORCID: https://orcid.org/0000-0003-0756-0767)
- Simon Francis Thomsen (ORCID: https://orcid.org/0000-0003-1575-9629)
- Páll T. Önundarson (ORCID: https://orcid.org/0000-0002-5342-9148)
- Christina Mikkelsen (ORCID: https://orcid.org/0000-0002-2945-6197)
- Asgeir Ö. Arnthórsson (ORCID: https://orcid.org/0000-0002-0087-2525)
- Søren Brunak (ORCID: https://orcid.org/0000-0003-0316-5866)
- Susan Mikkelsen (ORCID: https://orcid.org/0000-0001-7806-1143)
- Kristbjörg Bjarnadóttir
- Henrik Ullum (ORCID: https://orcid.org/0000-0001-7306-9058)
- Dóra Lúðvíksdóttir
- Erik Sørensen (ORCID: https://orcid.org/0000-0002-5002-9077)
- Kāri Stefánsson (ORCID: https://orcid.org/0000-0003-1676-864X)
- Páll Melsted (ORCID: https://orcid.org/0000-0002-8418-6724)
- Guðmar Þorleifsson (ORCID: https://orcid.org/0000-0003-4623-9087)
- Brynjar Viðarsson
- Saedís Saevarsdóttir (ORCID: https://orcid.org/0000-0001-9392-6184)
- Bárður Sigurgeirsson (ORCID: https://orcid.org/0000-0002-9733-9742)
- Björn R. Lúdvíksson (ORCID: https://orcid.org/0000-0002-6445-148X)
- Daníel F. Guðbjartsson (ORCID: https://orcid.org/0000-0002-5222-9857)
- Auðunn Skúta Snæbjarnarson (ORCID: https://orcid.org/0000-0002-3496-2991)
- Ísleifur Ólafsson (ORCID: https://orcid.org/0000-0002-3921-5805)
- Gudmundur L. Norddahl (ORCID: https://orcid.org/0000-0002-5622-7197)
- Ingileif Jónsdóttir (ORCID: https://orcid.org/0000-0001-8339-150X)
- Guðný Ella Thorlacius (ORCID: https://orcid.org/0000-0001-8997-4327)
- Erna V. Ivarsdottir (ORCID: https://orcid.org/0000-0002-2069-0681)
- Katla Kristjánsdóttir (ORCID: https://orcid.org/0000-0002-5837-895X)
- Maria Gunnbjörnsdóttir
- Sisse Rye Ostrowski (ORCID: https://orcid.org/0000-0001-5288-3851)
- Patrick Sulem (ORCID: https://orcid.org/0000-0001-7123-6123)
- Thorunn A. Olafsdottir (ORCID: https://orcid.org/0000-0001-5454-938X)
- Gudrun Rutsdottir (ORCID: https://orcid.org/0000-0001-6723-0757)
- Bitten Aagaard (ORCID: https://orcid.org/0000-0001-8306-1332)
- Unnur Steina Björnsdóttir (ORCID: https://orcid.org/0000-0002-7106-6678)
- Christian Erikstrup (ORCID: https://orcid.org/0000-0001-6551-6647)
- Ólöf Sigurðardóttir (ORCID: https://orcid.org/0000-0001-5347-1226)
- Vinicius Tragante (ORCID: https://orcid.org/0000-0002-8223-8957)
- Steinunn Guðmundsdóttir (ORCID: https://orcid.org/0000-0001-9317-0903)
- Celeste Porsbjerg (ORCID: https://orcid.org/0000-0003-4825-9436)
- Kristbjörg Gunnarsdóttir (ORCID: https://orcid.org/0000-0002-2623-5102)
- Guðmundur Einarsson (ORCID: https://orcid.org/0000-0002-1326-2339)
- Garðar Sveinbjörnsson (ORCID: https://orcid.org/0000-0003-2429-9468)
- Hilma Holm
- Ole Lederballe Pedersen
Institutions
- Statens Serum Institut (DK)
- University of Copenhagen (DK)
- deCODE Genetics (Iceland) (IS)
- University of Iceland (IS)
- Aarhus University (DK)
- Aalborg University Hospital (DK)
- Novo Nordisk Foundation (DK)
- Odense University Hospital (DK)
- Bispebjerg Hospital (DK)
- Aarhus University Hospital (DK)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- Zealand University Hospital (DK)
- Akureyri Hospital (IS)
- National University Hospital of Iceland (IS)
- Innovation Center Iceland (IS)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology
- Published
- 2024-10-16
- DOI
- https://doi.org/10.1016/j.jaci.2024.10.002
- Citations
- 5
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 1.41