A partial loss-of-function variant in STAT6 protects against type 2 asthma

A partial loss-of-function variant in STAT6 resulted in dampened IL-4 responses and protection from T2-high asthma, implicating STAT6 as an attractive therapeutic target.

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Publication Details

Journal
Journal of Allergy and Clinical Immunology
Published
2024-10-16
DOI
https://doi.org/10.1016/j.jaci.2024.10.002
Citations
5
Primary Topic
Cytokine Signaling Pathways and Interactions
Type
article
Field-Weighted Citation Impact
1.41
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A partial loss-of-function variant in STAT6 protects against type 2 asthma

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article

A partial loss-of-function variant in STAT6 protects against type 2 asthma

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article en
5 citations

Abstract

A partial loss-of-function variant in STAT6 resulted in dampened IL-4 responses and protection from T2-high asthma, implicating STAT6 as an attractive therapeutic target.

Journal of Allergy and Clinical ImmunologyVol. 155(1)
Statens Serum Institut (DK), University of Copenhagen (DK), deCODE Genetics (Iceland) (IS), University of Iceland (IS), Aarhus University (DK), Aalborg University Hospital (DK), Novo Nordisk Foundation (DK), Odense University Hospital (DK), Bispebjerg Hospital (DK), Aarhus University Hospital (DK), Copenhagen University Hospital (DK), Rigshospitalet (DK), Zealand University Hospital (DK), Akureyri Hospital (IS), National University Hospital of Iceland (IS), Innovation Center Iceland (IS)
Zero hunger
Openalex Percentile: Top 15%
Cytokine Signaling Pathways and Interactions
1.41
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